pentobarbital will minimize the extent or influence of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Lack of, or decreased reaction to tofacitinib might arise when coadministered with powerful CYP3A4 inducerspentobarbital will lower the extent or impact of vincristine by influencing hepatic/intestinal enzy